成果
複数の部局にまたがるINGEMの特性を⽣かして、多様な⼿法をもとに疾患の解明に迫る研究など、様々な論⽂成果が⽣まれています。
最近の主な成果
Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNFα NANOBODY® compound
AKT5 is a bona fide potassium channel and controls petiole growth in Arabidopsis
Age‐ and Sex‐Specific Better‐Ear Hearing Thresholds in Community‐Dwelling Japanese Adults
Suzuki J, Tozuka H, Takahashi H, Motoike IN, Sakurai M, et al.
Geriatrics & Gerontology International. 2026; 26(8).
doi:10.1111/ggi.70775
Geriatrics & Gerontology International. 2026; 26(8).
doi:10.1111/ggi.70775
Taxifolin impairs colonization of Clostridium perfringens in association with iron limitation-related physiological stress
Fadhilatunnur H, Gong W, Sato H, Hishinuma E, Matsukawa N, et al.
Microbiology Spectrum. 2026.
doi:10.1128/spectrum.01301-26
Microbiology Spectrum. 2026.
doi:10.1128/spectrum.01301-26
Oral Microbiome Alterations in Oral Lichen Planus Across Saliva, Dental Plaque, and Tongue Coating
ibSLS as a biobank for democratizing access to multi-omics data and biospecimens from spaceflight research
A rare variant in DPYD c.812delT causes severe adverse events of S-1 in a patient with tongue cancer
Ishimura H, Suehiro A, Hira D, Hishinuma E, Kato M, et al.
Cancer Chemotherapy and Pharmacology. 2026; 96(1):83.
doi:10.1007/s00280-026-04930-9
Cancer Chemotherapy and Pharmacology. 2026; 96(1):83.
doi:10.1007/s00280-026-04930-9
Evading disulfidptosis via NRF2 translation
Baird L,Yamamoto M.
Nature Cell Biology. 2026.
doi:10.1038/s41556-026-02036-1
Nature Cell Biology. 2026.
doi:10.1038/s41556-026-02036-1
Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)
Yoshihara K, Tanigawa T, Nishio S, Kanao H, Yoshino Y, et al.
Journal of Gynecologic Oncology. 2026; 38.
doi:10.3802/jgo.2027.38.e5
Journal of Gynecologic Oncology. 2026; 38.
doi:10.3802/jgo.2027.38.e5
Differences in reactive metabolite formation and cytochrome P450 binding between acetaminophen and its bicyclo[1.1.1]pentane bioisostere
Shibata M, Mizuno A, Nakayoshi T, Oda A, Nakajima M, et al.
Drug Metabolism and Pharmacokinetics. 2026; 69:101539.
doi:10.1016/j.dmpk.2026.101539
Drug Metabolism and Pharmacokinetics. 2026; 69:101539.
doi:10.1016/j.dmpk.2026.101539
Predicting poor efficacy of cabozantinib in advanced renal cell carcinoma by exploratory metabolic pathway analysis and in vitro verification
Clinical Utility of Comprehensive Genomic Profiling Tests Using MTB Management System at a Single Center in Japan
Population-Based Identification of Clonal Hematopoiesis Using Peripheral Blood Whole-Genome Sequencing in Japan
AI-Based Analysis of Tumor-Infiltrating Lymphocytes and Homologous Recombination in Ovarian Cancer: JGOG3025-A1 Study
Hamada K, Hamanishi J, Matsumura N, Ueda A, Takamatsu S, et al.
Cancer Science. 2026.
doi:10.1111/cas.70474
Cancer Science. 2026.
doi:10.1111/cas.70474
Compensation for impaired sensing of selenoprotein deficiency by alternative cysteine residues in KEAP1
Sato M, Iijima T, Suzuki T, Yamamoto M.
Redox Biology. 2026; 95:104263.
doi:10.1016/j.redox.2026.104263
Redox Biology. 2026; 95:104263.
doi:10.1016/j.redox.2026.104263
Intrinsically Disordered Polypeptides‐Based Stealth Materials Enable Enhanced Photothermal Cancer Therapy Using an In Situ Fiber‐Based Penetrating Laser System
Nishida K, Yamashita H, Takahashi A, Miyako E.
Small Science. 2026; 6(7).
doi:10.1002/smsc.70342
Small Science. 2026; 6(7).
doi:10.1002/smsc.70342
The ER anchoring and abundance of the EEF1B complex is affected by tissue-specific alternative EEF1D splicing
Jamous M, Hosogane M, Huang X, Suzuki M, Hatano A, et al.
Life Science Alliance. 2026; 9(8):e202503513.
doi:10.26508/lsa.202503513
Life Science Alliance. 2026; 9(8):e202503513.
doi:10.26508/lsa.202503513
Homozygous SGCB splice-site variant causes isolated dilated cardiomyopathy through sarcoglycan complex destabilization in East Asians
Li F, Shinomiya H, Kuramoto Y, Kanaoka K, Sakahashi Y, et al.
The Journal of Clinical Investigation. 2026; 136(11).
doi:10.1172/JCI198675
The Journal of Clinical Investigation. 2026; 136(11).
doi:10.1172/JCI198675
Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study
Association between multi-intensity olfactory test performance and the Montreal Cognitive Assessment score after adjustment for gray matter volume
Sato S, Imaeda T, Mugikura S, Mori N, Takanashi M, et al.
Scientific Reports. 2026.
doi:10.1038/s41598-026-61803-0
Scientific Reports. 2026.
doi:10.1038/s41598-026-61803-0
Study Protocol and Characteristics of the Wearable Device Survey for Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study
Chiba I, Nakaya N, Mugikura S, Kogure M, Hatanaka R, et al.
Journal of Epidemiology. 2026.
doi:10.2188/jea.JE20250540
Journal of Epidemiology. 2026.
doi:10.2188/jea.JE20250540
A Streamlined Synthesis of Adenosine Vinylsulfonamide Probes for Aminoacyl‐AMP Mimicry in NRPS.
Haraguchi N, Suto A, Matsui T, Kodera Y, Tanaka Y, et al.
ChemBioChem. 2026; 27(7).
doi:10.1002/cbic.70275
ChemBioChem. 2026; 27(7).
doi:10.1002/cbic.70275
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes.
Sato G, Yamamoto Y, Sonehara K, Saiki R, Ojima T, et al.
Nature Medicine. 2026.
doi:10.1038/s41591-026-04213-z
Nature Medicine. 2026.
doi:10.1038/s41591-026-04213-z
BCL11B enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL.
Mimura K, Kaino A, Ochi Y, Chang YH, Seki M, et al.
Blood. 2026.
doi:10.1182/blood.2025031466
Blood. 2026.
doi:10.1182/blood.2025031466
Bleeding Diathesis in Hypotrichosis–Lymphedema–Telangiectasia Syndrome due to Decreased von Willebrand Factor.
Kanno M, Sato H, Uemura Y, Meguro T, Ishigaki R, et al.
American Journal of Medical Genetics Part A. 2026.
doi:10.1002/ajmga.70068
American Journal of Medical Genetics Part A. 2026.
doi:10.1002/ajmga.70068
Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression.
Duan C, Yu Z, Li X, Sakai M, Maejima Y, et al.
Molecular Psychiatry. 2026.
doi:10.1038/s41380-026-03456-z
Molecular Psychiatry. 2026.
doi:10.1038/s41380-026-03456-z
NRF2 activation by CDDO-Im regulates inflammatory and autophagy pathways in human microglial cells.
Chu CT, Uruno A, Suzuki T, Taguchi K, Baird L, et al.
Free Radical Biology and Medicine. 2026; 243:318-337.
doi:10.1016/j.freeradbiomed.2025.11.046
Free Radical Biology and Medicine. 2026; 243:318-337.
doi:10.1016/j.freeradbiomed.2025.11.046
0.33 g mitigates muscle atrophy while 0.67 g preserves muscle function.
Tsuji R, Fujita R, Hayashi T, Sadaki S, Matsumoto T, et al.
Science Advances. 2026; 12(11).
doi:10.1126/sciadv.aed2258
Science Advances. 2026; 12(11).
doi:10.1126/sciadv.aed2258
Immunoreactivities of ZCCHC3 and Efp in the High‐Grade Serous and Clear Cell Ovarian Carcinomas Are Worse Prognostic Factors.
Iwabuchi E, Suzuki T, Ikeda K, Shibuya Y, Shigeta S, et al.
Pathology International. 2026; 76(2).
doi:10.1111/pin.70096
Pathology International. 2026; 76(2).
doi:10.1111/pin.70096
Prognostic impact of lymphadenectomy in patients with advanced ovarian clear cell carcinoma.
Fujiwara S, Shimada M, Ito Y, Takei Y, Kuroda T, et al.
International Journal of Clinical Oncology. 2026; 31(1):184-192.
doi:10.1007/s10147-025-02926-8
International Journal of Clinical Oncology. 2026; 31(1):184-192.
doi:10.1007/s10147-025-02926-8
Characterization of Genetic Polymorphisms Related to 5-FU Metabolizing Enzymes in Japanese Populations.
Hishinuma E.
Yakugaku Zasshi. 2026; 146(1).
doi:10.1248/yakushi.25-00124
Yakugaku Zasshi. 2026; 146(1).
doi:10.1248/yakushi.25-00124
Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence.
Shibuki T, Yamashita R, Hashimoto T, Fujisawa T, Imai M, et al.
International Journal of Clinical Oncology. 2026.
doi:10.1007/s10147-026-03001-6
International Journal of Clinical Oncology. 2026.
doi:10.1007/s10147-026-03001-6
Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population.
Lin Y, Sasado H, Sasahira N, Ueno M, Ishii H, et al.
Cancer Science. 2026.
doi:10.1111/cas.70344
Cancer Science. 2026.
doi:10.1111/cas.70344
AI-based quantification of tumor-infiltrating lymphocytes with integrative transcriptomics in ovarian clear cell carcinoma.
Hamada K, Hamanishi J, Ueda A, Takamatsu S, Yoshihara K, et al.
Cancer Immunology, Immunotherapy. 2026; 75(3):81.
doi:10.1007/s00262-026-04324-z
Cancer Immunology, Immunotherapy. 2026; 75(3):81.
doi:10.1007/s00262-026-04324-z
Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome.
Toyoshi E, Watanabe M, Namai F, Yamane K, Kashima T, et al.
Journal of Animal Science and Biotechnology. 2026; 17(1):32.
doi:10.1186/s40104-026-01364-4
Journal of Animal Science and Biotechnology. 2026; 17(1):32.
doi:10.1186/s40104-026-01364-4
Press release guide for genomic research and medicine: a framework co-developed with public contributors in Japan.
Arakawa M, Takeuchi T, Ebana Y, Muto K, Yoshida M, et al.
Journal of Human Genetics. 2026; 71(3):119-124.
doi:10.1038/s10038-026-01452-3
Journal of Human Genetics. 2026; 71(3):119-124.
doi:10.1038/s10038-026-01452-3
Correction: Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume.
Sato S, Imaeda T, Mugikura S, Mori N, Takanashi M, et al.
Scientific Reports. 2026; 16(1):7495.
doi:10.1038/s41598-026-40741-x
Scientific Reports. 2026; 16(1):7495.
doi:10.1038/s41598-026-40741-x
Disparities in adverse event perception between patients and healthcare providers in gynaecologic anticancer therapy.
Hashimoto H, Soejima A, Nishimura Y, Ike A, Sugawara M, et al.
BMJ Open. 2026; 16(2):e107743.
doi:10.1136/bmjopen-2025-107743
BMJ Open. 2026; 16(2):e107743.
doi:10.1136/bmjopen-2025-107743
Effect of Cytochrome P450 3A4 Genetic Polymorphisms on Heme Recognition by Using Molecular Dynamics Simulations.
Mizuno A, Nakayoshi T, Mizutani E, Hiratsuka M, Kato K, et al.
Biological and Pharmaceutical Bulletin. 2026; 49(3).
doi:10.1248/bpb.b26-00029
Biological and Pharmaceutical Bulletin. 2026; 49(3).
doi:10.1248/bpb.b26-00029
High-density lipoprotein mediates silica nanoparticle recognition by the multiligand receptor SR-B1.
Kurotobi M, Yamaguchi SI, Koyama H, Kinoshita K, Nakayama M.
Journal of Biological Chemistry. 2026; 302(3):111235.
doi:10.1016/j.jbc.2026.111235
Journal of Biological Chemistry. 2026; 302(3):111235.
doi:10.1016/j.jbc.2026.111235
Detection of Epigenetically Important 5-Formylcytosine Modifications Using Novel Photoreactive Oligonucleotides Containing a Trioxsalen-Conjugated Guanosine.
Mikame Y, Shirahama H, Doi K, Maekawa N, Kanazawa H, et al.
Journal of the American Chemical Society. 2026; 148(2):2220-2228.
doi:10.1021/jacs.5c11463
Journal of the American Chemical Society. 2026; 148(2):2220-2228.
doi:10.1021/jacs.5c11463
Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.
Li B, Kumada K, Shimada M, Shirota H, Tokunaga H, et al.
The Tohoku Journal of Experimental Medicine. 2026.
doi:10.1620/tjem.2025.J152
The Tohoku Journal of Experimental Medicine. 2026.
doi:10.1620/tjem.2025.J152
Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria.
Ishiguro K, Midorikawa K, Shigi N, Kimura S, Liiv A, et al.
Molecular Cell. 2026; 86(1):78-96.e10.
doi:10.1016/j.molcel.2025.11.018
Molecular Cell. 2026; 86(1):78-96.e10.
doi:10.1016/j.molcel.2025.11.018
Synthesis and structure-activity relationship of azithromycin derivatives against non-tuberculous mycobacteria.
Isozaki Y, Muzahid AA, Wakata T, Fujino M, Tanaka Y, et al.
European Journal of Medicinal Chemistry. 2026; 304:118520.
doi:10.1016/j.ejmech.2025.118520
European Journal of Medicinal Chemistry. 2026; 304:118520.
doi:10.1016/j.ejmech.2025.118520
Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril.
Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders.
Koketsu A, Fukase S, Tamahara T, Saito T, Ito A, et al.
Oral Diseases. 2026; 32(4):992-1003.
doi:10.1111/odi.70115
Oral Diseases. 2026; 32(4):992-1003.
doi:10.1111/odi.70115
