成果
複数の部局にまたがるINGEMの特性を生かして、多様な手法をもとに疾患の解明に迫る研究など、様々な論文成果が生まれています。
最近の主な成果
Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.
Aoki Y, Taguchi K, Anzawa H, Kawashima J, Ishida N, et al.
The Journal of Biochemistry. 2024.
doi: 10.1093/jb/mvae008
Dietary habits and plasma lipid concentrations in a general Japanese population.
Sato M, Hishinuma E, Matsukawa N, Shima Y, Saigusa D, et al.
Metabolomics. 2024; 20(2), 34.
doi: 10.1007/s11306-024-02087-1
Genetic etiology of truncus arteriosus excluding 22q11.2 deletion syndrome and identification of c.1617del, a prevalent variant in TMEM260, in the Japanese population.
Yaoita H, Kawai E, Takayama J, Iwasawa S, Saijo N, et al.
Journal of Human Genetics. 2024.
doi: 10.1038/s10038-024-01223-y
The Human Phenotype Ontology in 2024: phenotypes around the world.
Gargano MA, Matentzoglu N, Coleman B, Addo-Lartey EB, Anagnostopoulos AV, et al.
Nucleic Acids Research. 2024; 52(D1), D1333-D1346.
doi: 10.1093/nar/gkad1005
Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.
Tomono J, Asano K, Chiashi T, Suzuki M, Igarashi M, et al.
The Journal of Biochemistry. 2024.
doi: 10.1093/jb/mvae002
jMorp: Japanese Multi-Omics Reference Panel update report 2023
Tadaka S, Kawashima J, Hishinuma E, Saito S, Okamura Y, et al.
Nucleic acids research. 2024; 52(D1), D622-D632
doi: 10.1093/nar/gkad978
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Tanaka M, Yokoyama T, Saito H, Nishimoto M, Tsuda K, et al.
Nature chemical biology. 2024.
doi: 10.1038/s41589-023-01513-0
Exploration of urine metabolic biomarkers for new-onset, untreated pediatric epilepsy: A gas and liquid chromatography mass spectrometry-based metabolomics study.
Akiyama T, Saigusa D, Inoue T, Tokorodani C, Akiyama M, et al.
Brain and Development. 2024; 46(4), 180-186
doi: 10.1016/j.braindev.2023.12.004
Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources.
Shimizu M, Makiguchi M, Hishinuma E, Saito S, Hiratsuka M, Yamazaki H.
Drug Metabolism and Pharmacokinetics. 2024; 55, 100539.
doi: 10.1016/j.dmpk.2023.100539
Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
Itoh T, Omori Y, Seino M, Hirose K, Date F, et al.
Modern Pathology. 2024; 37(1), 100358.
doi: 10.1016/j.modpat.2023.100358
Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Saito Y, Sato K, Jinno S, Nakamura Y, Nobukuni T, et al.
Nutrients. 2023; 16(1), 145.
doi: 10.3390/nu16010145
Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.
Fujino M, Morito N, Hayashi T, Ojima M, Ishibashi S, et al.
Journal of Clinical Investigation Insight. 2023; 8(6).
doi: 10.1172/jci.insight.163306
Molecular Basis of the KEAP1-NRF2 Signaling Pathway.
Suzuki T, Takahashi J, Yamamoto M.
Molecules and Cells. 2023; 46(3), 133-141.
doi: 10.14348/molcells.2023.0028
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells.
Baird L, Taguchi K, Zhang A, Takahashi Y, Suzuki T, et al.
Redox Biology. 2023; 66, 102845.
doi: 10.1016/j.redox.2023.102845
Nrf2 activation improves experimental rheumatoid arthritis.
Zhang A, Suzuki T, Adachi S, Yoshida E, Sakaguchi S, Yamamoto M.
Free Radical Biology and Medicine. 2023; 207, 279-295.
doi: 10.1016/j.freeradbiomed.2023.07.016
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials.
Ishikawa T, Ogawa T, Shiihara M, Usubuchi H, Omori Y, et al.
iScience. 2023; 26(5), 106695.
doi: 10.1016/j.isci.2023.106695
Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity.
Kumondai M, Maekawa M, Hishinuma E, Sato Y, Sato T, et al.
Biological and Pharmaceutical Bulletin. 2023; 46(3), b22-00840.
doi: 10.1248/bpb.b22-00840
Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources.
Makiguchi M, Shimizu M, Yokota Y, Shimamura E, Hishinuma E, et al.
Drug Metabolism and Disposition. 2023; 51(7), 884-891.
doi: 10.1124/dmd.123.001310
Novel transporter screening technology for chemical production by microbial fermentation.
Nanatani K, Ishii T, Masuda A, Katsube S, Ando T, et al.
The Journal of General and Applied Microbiology. 2023; 69(3), 2022.12.002.
doi: 10.2323/jgam.2022.12.002
Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information.
Kudo H, Ishida N, Nobukuni T, Aoki Y, Saito S, et al.
Biopreservation and Biobanking. 2023.
doi. 10.1089/bio.2022.0211
Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance.
Baird L, Yamamoto M.
Redox Biology. 2023; 67, 102904.
doi: 10.1016/j.redox.2023.102904
Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study.
Ikejiri K, Suzuki T, Muto S, Takama H, Yamawaki K, et al.
Clinical and Experimental Nephrology. 2023.
doi: 10.1007/s10157-023-02427-w
Single-cell RNA-seq public data reveal the gene regulatory network landscape of respiratory epithelial and peripheral immune cells in COVID-19 patients.
Zhang L, Nishi H, Kinoshita K.
Frontiers in Immunology. 2023; 14.
doi: 10.3389/fimmu.2023.1194614
Global Proteomics for Identifying the Alteration Pathway of Niemann–Pick Disease Type C Using Hepatic Cell Models.
Miyoshi K, Hishinuma E, Matsukawa N, Shirasago Y, Watanabe M, et al.
International Journal of Molecular Sciences. 2023; 24(21), 15642.
doi: 10.3390/ijms242115642
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling.
Hishinuma E, Shimada M, Matsukawa N, Shima Y, Li B, et al.
Cancer & Metabolism. 2023; 11(1), 16.
doi: 10.1186/s40170-023-00317-z
Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8,380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation.
SATO Y, Hishinuma E, YAMAZAKI S, Ueda A, KUMONDAI M, et al.
Drug Metabolism and Disposition. 2023; DMD-AR-2023-001389.
doi: 10.1124/dmd.123.001389
Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes.
Kowalik MA, Taguchi K, Serra M, Andrea C, Elisabetta P, et al.
Hepatology. Published online August 21, 2023.
doi: 10.1097/HEP.0000000000000568
Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice.
Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, et al.
Communications Biology. 2023; 6(1), 875.
doi: 10.1038/s42003-023-05251-w
Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus.
Bui H B, Watanabe S, Nomura N, Liu K, Uemura T, et al.
Nature Communications. 2023; 14(1), 4770.
doi: 10.1038/s41467-023-40521-5
Management of patients with presumed germline pathogenic variant from tumor-only genomic sequencing: A retrospective analysis at a single facility.
Kawamura M, Shirota H, Niihori T, Komine K, Takahashi M, et al.
Journal of Human Genetics. 2023; 68(6), 399–408.
doi: 10.1038/s10038-023-01133-5
Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics.
Hishinuma E, Shimada M, Matsukawa N, Li B, Motoike IN, et al.
Journal of Obstetrics and Gynaecology Research. 2023; 49(8):2109-2117.
doi: 10.1111/jog.15709
これまでの成果はこちらから