成果





複数の部局にまたがるINGEMの特性を生かして、多様な手法をもとに疾患の解明に迫る研究など、様々な論文成果が生まれています。
最近の主な成果
Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril.
Yamamoto N, Inoue J, Saito R, Nanatani K, Takahashi A, et al.
Biochim Biophys Acta – Proteins Proteomics. 2025; 1874(1):141105.
doi:10.1016/j.bbapap.2025.141105
NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment.
Wen H, Suzuki T, Zhang A, Sato M, Matsumoto M, et al.
iScience. 2025; 28(10):113519.
doi:10.1016/j.isci.2025.113519
Symposium report—ethical and social considerations regarding return of secondary findings in atomic bomb survivors.
Yoshida N, Stewart DR, Uchimura A, Arita K, Bombard Y, et al.
Carcinogenesis. 2025; 46(3).
doi:10.1093/carcin/bgaf059
Bidirectional regulation of KEAP1 BTB domain-based sensor activity.
Suzuki T, Takagi K, Iso T, Wen H, Zhang A, et al.
Redox Biology. 2025; 87:103885.
doi:10.1016/j.redox.2025.103885
Advancements in Whole-Genome Sequencing Protocols: A Decade of In-House Operations and Quality Controls at the Tohoku Medical Megabank.
Katsuoka F, Kawashima J, Tadaka S, Otsuki A, Okamura Y, et al.
JMA Journal. 2025; 8(4).
doi:10.31662/jmaj.2025-0159
Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders.
Koketsu A, Fukase S, Tamahara T, Saito T, Ito A, et al.
Oral Diseases. 2025.
doi:10.1111/odi.70115
Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7.
Miyauchi Y, Koba H, Sawai M, Kansui H, Takechi S, et al.
Journal of Biological Chemistry. 2025; 301(9):110502.
doi:10.1016/j.jbc.2025.110502
Plasma Lysophosphatidylcholine Levels Correlate with Prognosis and Immunotherapy Response in Squamous Cell Carcinoma.
Iwasaki T, Shirota H, Hishinuma E, Kawaoka S, Matsukawa N, et al.
International Journal of Molecular Sciences. 2025; 26(15):7528.
doi:10.3390/ijms26157528
JG2: an updated version of the Japanese population-specific reference genome.
Sriwichaiin S, Makino S, Funayama T, Otsuki A, Kawashima J, et al.
Human Genome Variation. 2025; 12(1):21.
doi:10.1038/s41439-025-00326-y
Elucidation of the structure and molecular mechanisms of the aspartate antiporter.
Nanatani K, Guan L, Kanno R, Watanabe S, Katsube S, et al.
Communication Biology. 2025; 8(1):1359.
doi:10.1038/s42003-025-08676-7
Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population.
Ohmori Y, Hishinuma E, Suzuki Y, Ueda A, Kijogi CM, et al.
Biochemical Pharmacology. 2025; 242:117396.
doi:10.1016/j.bcp.2025.117396
Evaluation of the functional impact of rare CYP2C19 missense variants identified in understudied Populations: An Integrated in silico and in vitro analysis.
Saleous R, Hishinuma E, Al-Mahayri ZN, Ueda A, Suzuki Y, et al.
Biochemical Pharmacology. 2025; 242:117350.
doi:10.1016/j.bcp.2025.117350
Systemic activation of NRF2 contributes to the therapeutic efficacy of clinically-approved KRAS-G12C anti-cancer drugs.
Baird L, Zhang L, Hidaka T, Xi L, Wang K, et al.
British Journal of Cancer. 2025; 133(9):1377-1390.
doi:10.1038/s41416-025-03162-7
Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts.
Lin MR, Wu IW, Chou WH, Lin YF, Hung KY, et al.
Journal of Biomedical Science. 2025; 32(1):72.
doi:10.1186/s12929-025-01168-0
Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study.
Takase M, Nakaya N, Kogure M, Hatanaka R, Nakaya K, et al.
Cardiovascular Diabetology. 2025; 24(1):335.
doi:10.1186/s12933-025-02849-8
Protein Data Bank Japan: Computational Resources for Analysis of Protein Structures.
Bekker GJ, Nagao C, Shirota M, Nakamura T, Katayama T, et al.
Journal of Molecular Biology. 2025; 437(15):169013.
doi:10.1016/j.jmb.2025.169013
Unraveling the Trajectories from Health to Disease Onset Using Health Checkup Data.
Nagaie S, Mizuno S, Ogishima S.
Studies in Health Technology and Informatics. 2025; 7:329:1934-1935.
doi:10.3233/SHTI251286
Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement.
Sato K, Uehara S, Tsugita A, Ishii M, Ishiyama S, et al.
Cell Reports. 2025; 44(7):115965.
doi:10.1016/j.celrep.2025.115965
Development of AI Models for Early Prediction of Preterm Birth.
Mizuno S, Nagaie S, Tamiya G, Kuriyama S, Obara T, et al.
Studies in Health Technology and Informatics. 2025; 7:329:1932-1933.
doi:10.3233/SHTI251285
Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study.
Sawane K, Takahashi I, Ishikuro M, Takumi H, Orui M, et al.
Nutrition. 2025; 135:112739.
doi: 10.1016/j.nut.2025.112739
Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.
Fuse N, Anzawa H, Sakurai M, Motoike IN, Nagaie S, et al.
Ophthalmology Science. 2025; 5(5):100821.
doi: 10.1016/j.xops.2025.100821
STAT image reporting in a large-scale cohort: types, frequency, and insights from the Tohoku Medical Megabank Brain MRI Study.
Mori N, Mugikura S, Abe Y, Hozawa A, Fuse N, Yamamoto M.
Japanese Journal of Radiology. 2025.
doi: 10.1007/s11604-025-01800-x
Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis.
Sawahashi M, Kakuta Y, Naito T, Okazaki S, Ohneda K, et al.
Journal of Gastroenterology. 2025.
doi: 10.1007/s00535-025-02263-7
Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder.
Kobayashi M, Kobayashi T, Obara T, Narita A, Miyake A, et al.
The Tohoku Journal of Experimental Medicine. 2025; 2025.J074.
doi: 10.1620/tjem.2025.J074
Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.
Sawane K, Takahashi I, Ishikuro M, Takumi H, Orui M, et al.
The Journal of Nutrition. 2025; 155(5):1498-1507.
doi: 10.1016/j.tjnut.2025.02.024
The clinical-grade CBP/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs.
Wang K, Baird L, Yamamoto M.
Free Radical Biology and Medicine. 2025; 233:102-117.
doi: 10.1016/j.freeradbiomed.2025.03.034
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies.
Kodate S, Sato M, Hishinuma E, Kojima K, Motoike IN, et al.
scientific reports. 2025; 15(1):17035.
doi: 10.1038/s41598-025-01634-7
Transforming Biobanking with AI: Perspectives from Leading Experts.
Abdelhafiz AS, Henderson MK, Kozlakidis Z, Banerjee I, Mahajan G, et al.
Biopreserv Biobank. 2025.
doi: 10.1089/bio.2025.0101
Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study.
Hishinuma E, Shigeta S, Matsukawa N, Okamura Y, Motoike IN, et al.
International Journal of Molecular Sciences. 2025;26(12):5435.
doi: 10.3390/ijms26125435
Comparison of genotypes and phenotypes for von Willebrand factor gene variants using Japanese genome database.
Akimoto T, Inaba H, Ogishima S, Kumada K, Mitsuhashi A, et al.
Blood Vessels, Thrombosis & Hemostasis. 2025.
doi: 10.1016/j.bvth.2025.100070
Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population.
Ishida N, Harada S, Toki R, Hirata A, Matsumoto M, et al.
Journal of Diabetes Investigation. 2025.
doi: 10.1111/jdi.14377
Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits.
Toki R, Fushiki S, Kojima S, Sutoh Y, Otsuka-Yamasaki Y, et al.
Scientific Reports. 2025;15(1):14569.
doi: 10.1038/s41598-025-98992-z
Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study.
Nagino K, Akasaki Y, Fuse N, Ogishima S, Shimizu A, et al.
JMIR Research Protocols. 2025;14:e67862.
doi: 10.2196/67862
Prevalence and Associations of Epiretinal Membrane by OCT in a Japanese Population-Based Cohort: Tohoku Medical Megabank Organization Eye Study.
Shiraki A, Hirayama A, Fuse N, Kawasaki R, Fujimoto S, et al.
Ophthalmology Sciense. 2025;5(4):100752.
doi: 10.1016/j.xops.2025.100752
Double prenylation of budding yeast Ykt6 regulates cell wall integrity and autophagy.
Tateishi M, Goto K, Hishinuma E, Matsukawa N, Kishimoto T, et al.
Journal of Biological Chemistry. 2025;301(4):108384.
doi: 10.1016/j.jbc.2025.108384
Regional Differences in the Frequency of BRCA1 and BRCA2 Variants in Northeastern Japan: A Cohort Study.
Shirota H, Miyake A, Kawamura M, Suzuki S, Saito K, et al.
Cancer Medicine. 2025;14(8).
doi: doi:10.1002/cam4.70443
Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile.
Narita D, Hishinuma E, Ebina-Shibuya R, Miyauchi E, Matsukawa N, et al.
Lung Cancer. 2025;108082.
doi: 10.1016/j.lungcan.2025.108082
Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.
Mori N, Mugikura S, Hozawa A, Taira M, Hashizume H, et al.
The Tohoku Journal of Experimental Medicine. 2025;2025.J006.
doi: 10.1620/tjem.2025.J006
Shared decision-making in patients with gynecological cancer and healthcare professionals: a cross-sectional observational study in Japan.
Abe M, Hashimoto H, Soejima A, Nishimura Y, Ike A, et al.
Journal of Gynecologic Oncology. 2025;36.
doi: 10.3802/jgo.2025.36.e47
Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan.
Ohneda K, Suzuki Y, Hamanaka Y, Tadaka S, Shimada M, et al.
Journal of Human Genetics. 2025.
doi: 10.1038/s10038-024-01314-w
Breast cancer surveillance for epithelial ovarian cancer patients with BRCA1 and BRCA2 pathogenic variants: a single-center retrospective study.
Hasegawa-Minato J, Tochigi M, Miyahara S, Kudo K, Shibuya Y, et al.
Japanese Journal of Clinical Oncology. 2025.
doi: 10.1093/jjco/hyaf010
Protein Data Bank Japan: Improved tools for sequence‐oriented analysis of protein structures.
Bekker G, Nagao C, Shirota M, Nakamura T, Katayama T, et al.
Protein Science. 2025;34(3).
doi: 10.1002/pro.70052
Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages.
Aoyama Y, Yamazaki H, Nishimua K, Nomura M, Shigehiro T, et al.
Blood Journal . 2025.
doi: 10.1182/blood.2024025402
Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases
Suzuki N, Kojima K, Malvica S, Yamasaki K, Chikamatsu Y, et al.
Communications Medicine. 2025;5(1):3.
doi: 10.1038/s43856-024-00708-3
Creation of a macrolide antibiotic against non-tuberculous Mycobacterium using late-stage boron-mediated aglycon delivery.
Isozaki Y, Makikawa T, Kimura K, Nishihara D, Fujino M, et al.
Science Advances. 2025;11(10)
doi: 10.1126/sciadv.adt2352
Comprehensive Genome Profiling‐Initiated Tumor‐Informed Circulating Tumor DNA Monitoring for Patients With Advanced Cancer.
Sasaki T, Hiraki H, Yashima‐Abo A, Nagashima H, Endo F, et al.
Cancer Science. 2025
doi: 10.1111/cas.16446