English

成果

複数の部局にまたがるINGEMの特性を生かして、多様な手法をもとに疾患の解明に迫る研究など、様々な論文成果が生まれています。

最近の主な成果

Inconsistent embryo selection across polygenic score methods.

Namba S, Akiyama M, Hamanoue H, Kato K, Kawashima M, et al.
Nature Human Behaviour. 2024.
doi: 10.1038/s41562-024-02019-y

Specific cancer types and prognosis in patients with variations in the KEAP1-NRF2 system: A retrospective cohort study.

Iwasaki T, Shirota H, Sasaki K, Ouchi K, Nakayama Y, et al.
Cancer Science. 2024.
doi: 10.1111/cas.16355

Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study.

Sato S, Imaeda T, Mugikura S, Mori N, Takanashi M, et al.
Scientific Reports. 2024; 14(1):19138.
doi: 10.1038/s41598-024-69726-4

Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study.

Nagao S, Nishio S, Takehara K, Sato S, Satoh T, et al.
International Journal of Clinical Oncology. 2024; 29(10):1594-1601.
doi: 10.1007/s10147-024-02585-1

Niraparib as maintenance therapy in Japan: a retrospective observational study using a Japanese claims database.

Motohashi T, Shimada M, Tokunaga H, Kuwahara Y, Kuwabara H, et al.
Journal of Gynecologic Oncology. 2024.
doi: 10.3802/jgo. 2025.36.e19

Morphometric analysis of nuclear shape irregularity as a novel predictor of programmed death-ligand 1 expression in lung squamous cell carcinoma.

Saito-Koyama R, Tamai K, Yasuda J, Okamura Y, Yamazaki Y, et al.
Virchows Archiv. 2024; 484(4):609-620.
doi: 10.1007/s00428-023-03548-z

A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study.

Kiuchi S, Nakaya K, Cooray U, Takeuchi K, Motoike IN, et al.
Journal of Epidemiology. 2024.
doi: 10.2188/jea.JE20240099

Attitudes toward subsequent primary cancer prevention among survivors of childhood, adolescent, and young adult (CAYA) cancer in Japan: results of a comprehensive questionnaire survey on long-term women’s health after CAYA cancer.

Asai-Sato M, Takahashi T, Ota K, Komiya H, Iwase T, et al.
Journal of Gynecologic Oncology. 2024.
doi: 10.3802/jgo.2025.36.e29

A randomized phase II study of secondary cytoreductive surgery in patients with relapsed ovarian cancer who have progressed on a PARP inhibitor as first-line maintenance therapy: the SOCCER-P study (KGOG 3067/JGOG 3036/APGOT-OV11).

Cho HW, Kim HS, Park JY, Lee YY, Kim MC, et al.
International Journal of Gynecological Cancer. 2024; 34(11):1809-1812.
doi: 10.1136/ijgc-2024-005838

Heterogeneous treatment effect of dose‐dense paclitaxel plus carboplatin therapy for advanced ovarian cancer.

Taguchi A, Kato K, Furusawa A, Hara K, Sone K, et al.
International Journal of Cancer. 2024; 155(6):1068-1077.
doi: 10.1002/ijc.34996

Copy number variations in RNF216 and postsynaptic membrane-associated genes are associated with bipolar disorder: a case-control study in the Japanese population.

Nakatochi M, Kushima I, Aleksic B, Kimura H, Kato H, et al.
Psychiatry and Clinical Neurosciences. 2024.
doi: 10.1111/pcn.13752

Mobile infrared slit-light scanner for rapid eye disease screening.

Kaushik N, Sharma P, Himori N, Matsumoto T, Miya T, Nakazawa T.
Journal of Medical Imaging. 2024; 11(02).
doi: 10.1117/1.JMI.11.2.026003

Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort.

Sakurai M, Motoike IN, Hishinuma E, Aoki Y, Tadaka S, et al.
Scientific Reports. 2024; 14(1):15681.
doi: 10.1038/s41598-024-66180-0

Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project.

Kodama EN, Taira M, Kiyomoto H, Nakamura T, Nagaie S, et al.
JMA Journal. 2024; 7(3):342-352.
doi: 10.31662/jmaj.2023-0215

Two-stage strategy using denoising autoencoders for robust reference-free genotype imputation with missing input genotypes.

Kojima K, Tadaka S, Okamura Y, Kinoshita K.
Journal of Human Genetics. 2024; 69(10):511-518.
doi: 10.1038/s10038-024-01261-6

Molecular Mechanisms of Biotin in Modulating Inflammatory Diseases.

Sakurai-Yageta M, Suzuki Y.
Nutrients. 2024; 16(15):2444.
doi: 10.3390/nu16152444

How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Orui M, Obara T, Ishikuro M, Noda A, Shinoda G, et al.
JMA Journal. 2024; 7(3):353-363.
doi: 10.31662/jmaj.2024-0043

Liquid Chromatography/Tandem Mass Spectrometry-Based Simultaneous Analysis of 32 Bile Acids in Plasma and Conventional Biomarker-Integrated Diagnostic Screening Model Development for Hepatocellular Carcinoma.

Yamauchi M, Maekawa M, Sato T, Sato Y, Kumondai M, et al.
Metabolites. 2024; 14(9):513.
doi: doi:10.3390/metabo14090513

Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals.

Yamazaki S, Hishinuma E, Suzuki Y, Ueda A, Kijogi C, et al.
Biochemical Pharmacology. 2024; 229:116515.
doi: 10.1016/j.bcp.2024.116515

Sequential Sampling of the Gastrointestinal Tract to Characterize the Entire Digestive Microbiome in Japanese Subjects.

Ishizawa K, Tamahara T, Suzuki S, Hatayama Y, Li B, et al.
Microorganisms. 2024; 12(7):1324.
doi: 10.3390/microorganisms12071324

Multi-Omics Profiling Reveals Phenotypic and Functional Heterogeneity of Neutrophils in COVID-19.

Zhang L, Nishi H, Kinoshita K.
International Journal of Molecular Sciences. 2024; 25(7):3841.
doi: 10.3390/ijms25073841

Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.

Asano R, Takeuchi M, Nakakido M, Ito S, Aikawa C, et al.
Protein Science. 2024; 33(6)
doi: 10.1002/pro.5017

A fine‐scale genetic map of the Japanese population.

Takayama J, Makino S, Funayama T, Ueki M, Narita A, et al.
Clinical Genetics. 2024.
doi: 10.1111/cge.14536

Functional variants in a TTTG microsatellite on 15q26.1 cause familial nonautoimmune thyroid abnormalities.

Narumi S, Nagasaki K, Kiriya M, Uehara E, Akiba K, et al.
Nature Genetics. 2024; 56(5):869-876.
10.1038/s41588-024-01735-5

The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction.

Nakai T, Saigusa D, Kato K, Fukuuchi T, Koshiba S, et al.
Life Sciences. 2024; 346:122641
doi: 10.1016/j.lfs.2024.122641

“Rich arginine and strong positive charge” antimicrobial protein protamine: From its action on cell membranes to inhibition of bacterial vital functions.

Ookubo M, Tashiro Y, Asano K, Kamei Y, Tanaka Y, et al.
Biochimica et Biophysica Acta – Biomembranes. 2024; 1866(5):184323.
doi: 10.1016/j.bbamem.2024.184323

Molecular pathological demonstration of an unusual angiosarcoma‐like dedifferentiation pattern in hepatocellular carcinoma.

Murakami K, Itoh T, Okamura Y, Kinoshita K, Ota H, et al.
Pathology International. 2024; 74(3):157-159.
doi: 10.1111/pin.13412

Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations.

Kato K, Nakayoshi T, Hioki S, Hiratsuka M, Ishikawa Y, et al.
Biological and Pharmaceutical Bulletin. 2024; 47(3):b23-00908.
doi: 10.1248/bpb.b23-00908

Lenvatinib plus Pembrolizumab Combination Therapy for Advanced or Recurrent Endometrial Cancer: A Single-Center, Retrospective Analysis.

Tochigi M, Shigeta S, Shimada M, Miyahara S, Hasegawa-Minato J, et al.
The Tohoku Journal of Experimental Medicine. 2024; 262(2):2023.J095.
doi: 10.1620/tjem.2023.J095

Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women.

Mizuno S, Wagata M, Nagaie S, Ishikuro M, Obara T, et al.
Scientific Reports. 2024; 14(1):6292.
doi: 10.1038/s41598-024-55914-9

Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS).

Harada S, Iida M, Miyagawa N, Hirata A, Kuwabara K, et al.
Journal of Epidemiology. 2024.
doi: 10.2188/jea.JE20230192

Thermostability optimization of the aspartate/alanine exchange transporter from Tetragenococcus halophilus.

Kunii K, Yamanaka T, Miyamoto A, Nanatani K, Abe K.
The Journal of Biochemistry. 2024; 175(4):439-446.
doi: 10.1093/jb/mvad104

Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.

Aoki Y, Taguchi K, Anzawa H, Kawashima J, Ishida N, et al.
The Journal of Biochemistry. 2024.
doi: 10.1093/jb/mvae008

Dietary habits and plasma lipid concentrations in a general Japanese population.

Sato M, Hishinuma E, Matsukawa N, Shima Y, Saigusa D, et al.
Metabolomics. 2024; 20(2), 34.
doi: 10.1007/s11306-024-02087-1

Genetic etiology of truncus arteriosus excluding 22q11.2 deletion syndrome and identification of c.1617del, a prevalent variant in TMEM260, in the Japanese population.

Yaoita H, Kawai E, Takayama J, Iwasawa S, Saijo N, et al.
Journal of Human Genetics. 2024.
doi: 10.1038/s10038-024-01223-y

The Human Phenotype Ontology in 2024: phenotypes around the world.

Gargano MA, Matentzoglu N, Coleman B, Addo-Lartey EB, Anagnostopoulos AV, et al.
Nucleic Acids Research. 2024; 52(D1):D1333-D1346.
doi: 10.1093/nar/gkad1005

Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.

Tomono J, Asano K, Chiashi T, Suzuki M, Igarashi M, et al.
The Journal of Biochemistry. 2024.
doi: 10.1093/jb/mvae002

jMorp: Japanese Multi-Omics Reference Panel update report 2023

Tadaka S, Kawashima J, Hishinuma E, Saito S, Okamura Y, et al.
Nucleic acids research. 2024; 52(D1):D622-D632
doi: 10.1093/nar/gkad978

Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.

Tanaka M, Yokoyama T, Saito H, Nishimoto M, Tsuda K, et al.
Nature chemical biology. 2024.
doi: 10.1038/s41589-023-01513-0

Exploration of urine metabolic biomarkers for new-onset, untreated pediatric epilepsy: A gas and liquid chromatography mass spectrometry-based metabolomics study.

Akiyama T, Saigusa D, Inoue T, Tokorodani C, Akiyama M, et al.
Brain and Development. 2024.
doi: 10.1016/j.braindev.2023.12.004

Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources.

Shimizu M, Makiguchi M, Hishinuma E, Saito S, Hiratsuka M, Yamazaki H.
Drug Metabolism and Pharmacokinetics. 2024; 55:100539.
doi: 10.1016/j.dmpk.2023.100539

Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.

Itoh T, Omori Y, Seino M, Hirose K, Date F, et al.
Modern Pathology. 2024; 37(1), 100358.
doi: 10.1016/j.modpat.2023.100358

これまでの成果
2023 / 2022 / 2021 / -2020