English

成果

複数の部局にまたがるINGEMの特性を生かして、多様な手法をもとに疾患の解明に迫る研究など、様々な論文成果が生まれています。

最近の主な成果

The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction.

Nakai T, Saigusa D, Kato K, Fukuuchi T, Koshiba S, et al.
Life Sciences. 2024; 346:122641
doi: 10.1016/j.lfs.2024.122641

“Rich arginine and strong positive charge” antimicrobial protein protamine: From its action on cell membranes to inhibition of bacterial vital functions.

Ookubo M, Tashiro Y, Asano K, Kamei Y, Tanaka Y, et al.
Biochimica et Biophysica Acta – Biomembranes. 2024; 1866(5):184323.
doi: 10.1016/j.bbamem.2024.184323

Molecular pathological demonstration of an unusual angiosarcoma‐like dedifferentiation pattern in hepatocellular carcinoma.

Murakami K, Itoh T, Okamura Y, Kinoshita K, Ota H, et al.
Pathology International. 2024; 74(3):157-159.
doi: 10.1111/pin.13412

Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations.

Kato K, Nakayoshi T, Hioki S, Hiratsuka M, Ishikawa Y, et al.
Biological and Pharmaceutical Bulletin. 2024; 47(3):b23-00908.
doi: 10.1248/bpb.b23-00908

Lenvatinib plus Pembrolizumab Combination Therapy for Advanced or Recurrent Endometrial Cancer: A Single-Center, Retrospective Analysis.

Tochigi M, Shigeta S, Shimada M, Miyahara S, Hasegawa-Minato J, et al.
The Tohoku Journal of Experimental Medicine. 2024; 262(2):2023.J095.
doi: 10.1620/tjem.2023.J095

Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women.

Mizuno S, Wagata M, Nagaie S, Ishikuro M, Obara T, et al.
Scientific Reports. 2024; 14(1):6292.
doi: 10.1038/s41598-024-55914-9

Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS).

Harada S, Iida M, Miyagawa N, Hirata A, Kuwabara K, et al.
Journal of Epidemiology. 2024.
doi: 10.2188/jea.JE20230192

Thermostability optimization of the aspartate/alanine exchange transporter from Tetragenococcus halophilus.

Kunii K, Yamanaka T, Miyamoto A, Nanatani K, Abe K.
The Journal of Biochemistry. 2024; 175(4):439-446.
doi: 10.1093/jb/mvad104

Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.

Aoki Y, Taguchi K, Anzawa H, Kawashima J, Ishida N, et al.
The Journal of Biochemistry. 2024.
doi: 10.1093/jb/mvae008

Dietary habits and plasma lipid concentrations in a general Japanese population.

Sato M, Hishinuma E, Matsukawa N, Shima Y, Saigusa D, et al.
Metabolomics. 2024; 20(2), 34.
doi: 10.1007/s11306-024-02087-1

Genetic etiology of truncus arteriosus excluding 22q11.2 deletion syndrome and identification of c.1617del, a prevalent variant in TMEM260, in the Japanese population.

Yaoita H, Kawai E, Takayama J, Iwasawa S, Saijo N, et al.
Journal of Human Genetics. 2024.
doi: 10.1038/s10038-024-01223-y

The Human Phenotype Ontology in 2024: phenotypes around the world.

Gargano MA, Matentzoglu N, Coleman B, Addo-Lartey EB, Anagnostopoulos AV, et al.
Nucleic Acids Research. 2024; 52(D1):D1333-D1346.
doi: 10.1093/nar/gkad1005

Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.

Tomono J, Asano K, Chiashi T, Suzuki M, Igarashi M, et al.
The Journal of Biochemistry. 2024.
doi: 10.1093/jb/mvae002

jMorp: Japanese Multi-Omics Reference Panel update report 2023

Tadaka S, Kawashima J, Hishinuma E, Saito S, Okamura Y, et al.
Nucleic acids research. 2024; 52(D1):D622-D632
doi: 10.1093/nar/gkad978

Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.

Tanaka M, Yokoyama T, Saito H, Nishimoto M, Tsuda K, et al.
Nature chemical biology. 2024.
doi: 10.1038/s41589-023-01513-0

Exploration of urine metabolic biomarkers for new-onset, untreated pediatric epilepsy: A gas and liquid chromatography mass spectrometry-based metabolomics study.

Akiyama T, Saigusa D, Inoue T, Tokorodani C, Akiyama M, et al.
Brain and Development. 2024.
doi: 10.1016/j.braindev.2023.12.004

Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources.

Shimizu M, Makiguchi M, Hishinuma E, Saito S, Hiratsuka M, Yamazaki H.
Drug Metabolism and Pharmacokinetics. 2024; 55:100539.
doi: 10.1016/j.dmpk.2023.100539

Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.

Itoh T, Omori Y, Seino M, Hirose K, Date F, et al.
Modern Pathology. 2024; 37(1), 100358.
doi: 10.1016/j.modpat.2023.100358

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