Results

INGEM produces a wide range of research achievements by bringing together expertise across multiple departments and using diverse approaches to understand disease.

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Recent Major Results

A rare variant in DPYD c.812delT causes severe adverse events of S-1 in a patient with tongue cancer

Ishimura H, Suehiro A, Hira D, Hishinuma E, Kato M, et al.
Cancer Chemotherapy and Pharmacology. 2026; 96(1):83.
doi:10.1007/s00280-026-04930-9

Evading disulfidptosis via NRF2 translation

Baird L,Yamamoto M.
Nature Cell Biology. 2026.
doi:10.1038/s41556-026-02036-1

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

Yoshihara K, Tanigawa T, Nishio S, Kanao H, Yoshino Y, et al.
Journal of Gynecologic Oncology. 2026; 38.
doi:10.3802/jgo.2027.38.e5

Differences in reactive metabolite formation and cytochrome P450 binding between acetaminophen and its bicyclo[1.1.1]pentane bioisostere

Shibata M, Mizuno A, Nakayoshi T, Oda A, Nakajima M, et al.
Drug Metabolism and Pharmacokinetics. 2026; 69:101539.
doi:10.1016/j.dmpk.2026.101539

Predicting poor efficacy of cabozantinib in advanced renal cell carcinoma by exploratory metabolic pathway analysis and in vitro verification

Sakai T, Kawasaki Y, Sakamoto I, Hishinuma E, Matsukawa N, et al.
Cancer Medicine. 2026.
doi:10.1002/cam4.72145

Clinical Utility of Comprehensive Genomic Profiling Tests Using MTB Management System at a Single Center in Japan

Sarudate C, Dobashi M, Kawamura M, Shirota H, Iwasaki T, et al.
Scientific Reports. 2026.
doi:10.1038/s41598-026-61124-2

Population-Based Identification of Clonal Hematopoiesis Using Peripheral Blood Whole-Genome Sequencing in Japan

Chi S, Motoike IN, Fujisawa T, Yamaguchi-Kabata Y, Nobukuni T, et al.
Cancer Science. 2026; 117(7):1996-2006.
doi:10.1111/cas.70406

AI-Based Analysis of Tumor-Infiltrating Lymphocytes and Homologous Recombination in Ovarian Cancer: JGOG3025-A1 Study

Hamada K, Hamanishi J, Matsumura N, Ueda A, Takamatsu S, et al.
Cancer Science. 2026.
doi:10.1111/cas.70474

Compensation for impaired sensing of selenoprotein deficiency by alternative cysteine residues in KEAP1

Sato M, Iijima T, Suzuki T, Yamamoto M.
Redox Biology. 2026; 95:104263.
doi:10.1016/j.redox.2026.104263

Intrinsically Disordered Polypeptides‐Based Stealth Materials Enable Enhanced Photothermal Cancer Therapy Using an In Situ Fiber‐Based Penetrating Laser System

Nishida K, Yamashita H, Takahashi A, Miyako E.
Small Science. 2026; 6(7).
doi:10.1002/smsc.70342

The ER anchoring and abundance of the EEF1B complex is affected by tissue-specific alternative EEF1D splicing

Jamous M, Hosogane M, Huang X, Suzuki M, Hatano A, et al.
Life Science Alliance. 2026; 9(8):e202503513.
doi:10.26508/lsa.202503513

Homozygous SGCB splice-site variant causes isolated dilated cardiomyopathy through sarcoglycan complex destabilization in East Asians

Li F, Shinomiya H, Kuramoto Y, Kanaoka K, Sakahashi Y, et al.
The Journal of Clinical Investigation. 2026; 136(11).
doi:10.1172/JCI198675

Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study

Satake M, Chiba I, Kogure M, Hatanaka R, Nakaya K, et al.
Journal of Atherosclerosis and Thrombosis. 2026; 33(8):65993.
doi:10.5551/jat.65993

Association between multi-intensity olfactory test performance and the Montreal Cognitive Assessment score after adjustment for gray matter volume

Sato S, Imaeda T, Mugikura S, Mori N, Takanashi M, et al.
Scientific Reports. 2026.
doi:10.1038/s41598-026-61803-0

Study Protocol and Characteristics of the Wearable Device Survey for Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study

Chiba I, Nakaya N, Mugikura S, Kogure M, Hatanaka R, et al.
Journal of Epidemiology. 2026.
doi:10.2188/jea.JE20250540

A Streamlined Synthesis of Adenosine Vinylsulfonamide Probes for Aminoacyl‐AMP Mimicry in NRPS.

Haraguchi N, Suto A, Matsui T, Kodera Y, Tanaka Y, et al.
ChemBioChem. 2026; 27(7).
doi:10.1002/cbic.70275

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes.

Sato G, Yamamoto Y, Sonehara K, Saiki R, Ojima T, et al.
Nature Medicine. 2026.
doi:10.1038/s41591-026-04213-z

BCL11B enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL.

Mimura K, Kaino A, Ochi Y, Chang YH, Seki M, et al.
Blood. 2026.
doi:10.1182/blood.2025031466

Bleeding Diathesis in Hypotrichosis–Lymphedema–Telangiectasia Syndrome due to Decreased von Willebrand Factor.

Kanno M, Sato H, Uemura Y, Meguro T, Ishigaki R, et al.
American Journal of Medical Genetics Part A. 2026.
doi:10.1002/ajmga.70068

Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression.

Duan C, Yu Z, Li X, Sakai M, Maejima Y, et al.
Molecular Psychiatry. 2026.
doi:10.1038/s41380-026-03456-z

NRF2 activation by CDDO-Im regulates inflammatory and autophagy pathways in human microglial cells.

Chu CT, Uruno A, Suzuki T, Taguchi K, Baird L, et al.
Free Radical Biology and Medicine. 2026; 243:318-337.
doi:10.1016/j.freeradbiomed.2025.11.046

0.33 g mitigates muscle atrophy while 0.67 g preserves muscle function.

Tsuji R, Fujita R, Hayashi T, Sadaki S, Matsumoto T, et al.
Science Advances. 2026; 12(11).
doi:10.1126/sciadv.aed2258

Immunoreactivities of ZCCHC3 and Efp in the High‐Grade Serous and Clear Cell Ovarian Carcinomas Are Worse Prognostic Factors.

Iwabuchi E, Suzuki T, Ikeda K, Shibuya Y, Shigeta S, et al.
Pathology International. 2026; 76(2).
doi:10.1111/pin.70096

Prognostic impact of lymphadenectomy in patients with advanced ovarian clear cell carcinoma.

Fujiwara S, Shimada M, Ito Y, Takei Y, Kuroda T, et al.
International Journal of Clinical Oncology. 2026; 31(1):184-192.
doi:10.1007/s10147-025-02926-8

Characterization of Genetic Polymorphisms Related to 5-FU Metabolizing Enzymes in Japanese Populations.

Hishinuma E.
Yakugaku Zasshi. 2026; 146(1).
doi:10.1248/yakushi.25-00124

Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence.

Shibuki T, Yamashita R, Hashimoto T, Fujisawa T, Imai M, et al.
International Journal of Clinical Oncology. 2026.
doi:10.1007/s10147-026-03001-6

Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population.

Lin Y, Sasado H, Sasahira N, Ueno M, Ishii H, et al.
Cancer Science. 2026.
doi:10.1111/cas.70344

AI-based quantification of tumor-infiltrating lymphocytes with integrative transcriptomics in ovarian clear cell carcinoma.

Hamada K, Hamanishi J, Ueda A, Takamatsu S, Yoshihara K, et al.
Cancer Immunology, Immunotherapy. 2026; 75(3):81.
doi:10.1007/s00262-026-04324-z

Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome.

Toyoshi E, Watanabe M, Namai F, Yamane K, Kashima T, et al.
Journal of Animal Science and Biotechnology. 2026; 17(1):32.
doi:10.1186/s40104-026-01364-4

Press release guide for genomic research and medicine: a framework co-developed with public contributors in Japan.

Arakawa M, Takeuchi T, Ebana Y, Muto K, Yoshida M, et al.
Journal of Human Genetics. 2026; 71(3):119-124.
doi:10.1038/s10038-026-01452-3

Correction: Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume.

Sato S, Imaeda T, Mugikura S, Mori N, Takanashi M, et al.
Scientific Reports. 2026; 16(1):7495.
doi:10.1038/s41598-026-40741-x

Disparities in adverse event perception between patients and healthcare providers in gynaecologic anticancer therapy.

Hashimoto H, Soejima A, Nishimura Y, Ike A, Sugawara M, et al.
BMJ Open. 2026; 16(2):e107743.
doi:10.1136/bmjopen-2025-107743

Effect of Cytochrome P450 3A4 Genetic Polymorphisms on Heme Recognition by Using Molecular Dynamics Simulations.

Mizuno A, Nakayoshi T, Mizutani E, Hiratsuka M, Kato K, et al.
Biological and Pharmaceutical Bulletin. 2026; 49(3).
doi:10.1248/bpb.b26-00029

High-density lipoprotein mediates silica nanoparticle recognition by the multiligand receptor SR-B1.

Kurotobi M, Yamaguchi SI, Koyama H, Kinoshita K, Nakayama M.
Journal of Biological Chemistry. 2026; 302(3):111235.
doi:10.1016/j.jbc.2026.111235

Detection of Epigenetically Important 5-Formylcytosine Modifications Using Novel Photoreactive Oligonucleotides Containing a Trioxsalen-Conjugated Guanosine.

Mikame Y, Shirahama H, Doi K, Maekawa N, Kanazawa H, et al.
Journal of the American Chemical Society. 2026; 148(2):2220-2228.
doi:10.1021/jacs.5c11463

Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.

Li B, Kumada K, Shimada M, Shirota H, Tokunaga H, et al.
The Tohoku Journal of Experimental Medicine. 2026.
doi:10.1620/tjem.2025.J152

Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria.

Ishiguro K, Midorikawa K, Shigi N, Kimura S, Liiv A, et al.
Molecular Cell. 2026; 86(1):78-96.e10.
doi:10.1016/j.molcel.2025.11.018

Synthesis and structure-activity relationship of azithromycin derivatives against non-tuberculous mycobacteria.

Isozaki Y, Muzahid AA, Wakata T, Fujino M, Tanaka Y, et al.
European Journal of Medicinal Chemistry. 2026; 304:118520.
doi:10.1016/j.ejmech.2025.118520

Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril.

Yamamoto N, Inoue J, Saito R, Nanatani K, Takahashi A, et al.
Biochim Biophys Acta – Proteins Proteomics. 2025; 1874(1):141105.
doi:10.1016/j.bbapap.2025.141105

Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders.

Koketsu A, Fukase S, Tamahara T, Saito T, Ito A, et al.
Oral Diseases. 2026; 32(4):992-1003.
doi:10.1111/odi.70115

Transforming Biobanking with AI: Perspectives from Leading Experts.

Abdelhafiz AS, Henderson MK, Kozlakidis Z, Banerjee I, Mahajan G, et al.
Biopreserv Biobank. 2026; 24(3):209-215.
doi:10.1089/bio.2025.0101

Past Results

Usage Guide

  • Cryo-Electron Microscope Usage Guide
  • Support for Disease Model Animal Generation and Analysis (Campus Only)
  • Biobank Cross Search (Campus Only)
  • Metabolome Analysis Support
  • Proteome Analysis Support
  • Metagenome Analysis Support

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