Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study.

Sawane K, Takahashi I, Ishikuro M, Takumi H, Orui M, et al.
Nutrition. 2025; 135:112739.
doi: 10.1016/j.nut.2025.112739

Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.

Fuse N, Anzawa H, Sakurai M, Motoike IN, Nagaie S, et al.
Ophthalmology Science. 2025; 5(5):100821.
doi: 10.1016/j.xops.2025.100821

STAT image reporting in a large-scale cohort: types, frequency, and insights from the Tohoku Medical Megabank Brain MRI Study.

Mori N, Mugikura S, Abe Y, Hozawa A, Fuse N, Yamamoto M.
Japanese Journal of Radiology. 2025.
doi: 10.1007/s11604-025-01800-x

Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis.

Sawahashi M, Kakuta Y, Naito T, Okazaki S, Ohneda K, et al.
Journal of Gastroenterology. 2025.
doi: 10.1007/s00535-025-02263-7

Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder.

Kobayashi M, Kobayashi T, Obara T, Narita A, Miyake A, et al.
The Tohoku Journal of Experimental Medicine. 2025; 2025.J074.
doi: 10.1620/tjem.2025.J074

Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Sawane K, Takahashi I, Ishikuro M, Takumi H, Orui M, et al.
The Journal of Nutrition. 2025; 155(5):1498-1507.
doi: 10.1016/j.tjnut.2025.02.024

The clinical-grade CBP/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs.

Wang K, Baird L, Yamamoto M.
Free Radical Biology and Medicine. 2025; 233:102-117.
doi: 10.1016/j.freeradbiomed.2025.03.034

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies.

Kodate S, Sato M, Hishinuma E, Kojima K, Motoike IN, et al.
scientific reports. 2025; 15(1):17035.
doi: 10.1038/s41598-025-01634-7

Transforming Biobanking with AI: Perspectives from Leading Experts.

Abdelhafiz AS, Henderson MK, Kozlakidis Z, Banerjee I, Mahajan G, et al.
Biopreserv Biobank. 2025.
doi: 10.1089/bio.2025.0101

Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study.

Hishinuma E, Shigeta S, Matsukawa N, Okamura Y, Motoike IN, et al.
International Journal of Molecular Sciences. 2025;26(12):5435.
doi: 10.3390/ijms26125435

Comparison of genotypes and phenotypes for von Willebrand factor gene variants using Japanese genome database.

Akimoto T, Inaba H, Ogishima S, Kumada K, Mitsuhashi A, et al.
Blood Vessels, Thrombosis & Hemostasis. 2025.
doi: 10.1016/j.bvth.2025.100070

Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population.

Ishida N, Harada S, Toki R, Hirata A, Matsumoto M, et al.
Journal of Diabetes Investigation. 2025.
doi: 10.1111/jdi.14377

Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits.

Toki R, Fushiki S, Kojima S, Sutoh Y, Otsuka-Yamasaki Y, et al.
Scientific Reports. 2025;15(1):14569.
doi: 10.1038/s41598-025-98992-z

Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study.

Nagino K, Akasaki Y, Fuse N, Ogishima S, Shimizu A, et al.
JMIR Research Protocols. 2025;14:e67862.
doi: 10.2196/67862

Prevalence and Associations of Epiretinal Membrane by OCT in a Japanese Population-Based Cohort: Tohoku Medical Megabank Organization Eye Study.

Shiraki A, Hirayama A, Fuse N, Kawasaki R, Fujimoto S, et al.
Ophthalmology Sciense. 2025;5(4):100752.
doi: 10.1016/j.xops.2025.100752

Double prenylation of budding yeast Ykt6 regulates cell wall integrity and autophagy.

Tateishi M, Goto K, Hishinuma E, Matsukawa N, Kishimoto T, et al.
Journal of Biological Chemistry. 2025;301(4):108384.
doi: 10.1016/j.jbc.2025.108384

Regional Differences in the Frequency of BRCA1 and BRCA2 Variants in Northeastern Japan: A Cohort Study.

Shirota H, Miyake A, Kawamura M, Suzuki S, Saito K, et al.
Cancer Medicine. 2025;14(8).
doi: doi:10.1002/cam4.70443

Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile.

Narita D, Hishinuma E, Ebina-Shibuya R, Miyauchi E, Matsukawa N, et al.
Lung Cancer. 2025;108082.
doi: 10.1016/j.lungcan.2025.108082

Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.

Mori N, Mugikura S, Hozawa A, Taira M, Hashizume H, et al.
The Tohoku Journal of Experimental Medicine. 2025;2025.J006.
doi: 10.1620/tjem.2025.J006

Shared decision-making in patients with gynecological cancer and healthcare professionals: a cross-sectional observational study in Japan.

Abe M, Hashimoto H, Soejima A, Nishimura Y, Ike A, et al.
Journal of Gynecologic Oncology. 2025;36.
doi: 10.3802/jgo.2025.36.e47

Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan.

Ohneda K, Suzuki Y, Hamanaka Y, Tadaka S, Shimada M, et al.
Journal of Human Genetics. 2025.
doi: 10.1038/s10038-024-01314-w

Breast cancer surveillance for epithelial ovarian cancer patients with BRCA1 and BRCA2 pathogenic variants: a single-center retrospective study.

Hasegawa-Minato J, Tochigi M, Miyahara S, Kudo K, Shibuya Y, et al.
Japanese Journal of Clinical Oncology. 2025. 
doi: 10.1093/jjco/hyaf010

Protein Data Bank Japan: Improved tools for sequence‐oriented analysis of protein structures.

Bekker G, Nagao C, Shirota M, Nakamura T, Katayama T, et al.
Protein Science. 2025;34(3).
doi: 10.1002/pro.70052

Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages.

Aoyama Y, Yamazaki H, Nishimua K, Nomura M, Shigehiro T, et al.
Blood Journal . 2025.
doi: 10.1182/blood.2024025402

Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases

Suzuki N, Kojima K, Malvica S, Yamasaki K, Chikamatsu Y, et al.
Communications Medicine. 2025;5(1):3.
doi: 10.1038/s43856-024-00708-3

Creation of a macrolide antibiotic against non-tuberculous Mycobacterium using late-stage boron-mediated aglycon delivery.

Isozaki Y, Makikawa T, Kimura K, Nishihara D, Fujino M, et al.
Science Advances. 2025;11(10)
doi: 10.1126/sciadv.adt2352

Comprehensive Genome Profiling‐Initiated Tumor‐Informed Circulating Tumor DNA Monitoring for Patients With Advanced Cancer.

Sasaki T, Hiraki H, Yashima‐Abo A, Nagashima H, Endo F, et al.
Cancer Science. 2025.
doi: 10.1111/cas.16446