{"id":1467,"date":"2023-12-15T10:57:12","date_gmt":"2023-12-15T01:57:12","guid":{"rendered":"https:\/\/www.ingem.oas.tohoku.ac.jp\/?page_id=1467"},"modified":"2026-04-20T11:44:50","modified_gmt":"2026-04-20T02:44:50","slug":"achievement","status":"publish","type":"page","link":"https:\/\/www.ingem.oas.tohoku.ac.jp\/english\/achievement","title":{"rendered":"Achievement"},"content":{"rendered":"
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Achievement<\/h2>\n

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The characteristics of INGEM, which spans multiple departments, have produced a variety of thesis results, including research that has led to the elucidation of diseases based on a variety of methods.<\/p>\n

Recent Major Achievements<\/h3>\n
\n

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes.<\/p>\n

Sato G, Yamamoto Y, Sonehara K, Saiki R, Ojima T, et al.
\nNature Medicine.<\/em> 2026.
\ndoi:10.1038\/s41591-026-04213-z<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

BCL11B enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL.<\/p>\n

Mimura K, Kaino A, Ochi Y, Chang YH, Seki M, et al.
\nBlood.<\/em> 2026.
\ndoi:10.1182\/blood.2025031466<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Bleeding Diathesis in Hypotrichosis\u2013Lymphedema\u2013Telangiectasia Syndrome due to Decreased von Willebrand Factor.<\/p>\n

Kanno M, Sato H, Uemura Y, Meguro T, Ishigaki R, et al.
\nAmerican Journal of Medical Genetics Part A.<\/em> 2026.
\ndoi:10.1002\/ajmga.70068<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression.<\/p>\n

Duan C, Yu Z, Li X, Sakai M, Maejima Y, et al.
\nMolecular Psychiatry.<\/em> 2026.
\ndoi:10.1038\/s41380-026-03456-z<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

NRF2 activation by CDDO-Im regulates inflammatory and autophagy pathways in human microglial cells.<\/p>\n

Chu CT, Uruno A, Suzuki T, Taguchi K, Baird L, et al.
\nFree Radical Biology and Medicine.<\/em> 2026; 243:318-337.
\ndoi:10.1016\/j.freeradbiomed.2025.11.046<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

0.33 g mitigates muscle atrophy while 0.67 g preserves muscle function.<\/p>\n

Tsuji R, Fujita R, Hayashi T, Sadaki S, Matsumoto T, et al.
\nScience Advances.<\/em> 2026; 12(11).
\ndoi:10.1126\/sciadv.aed2258<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Immunoreactivities of ZCCHC3 and Efp in the High\u2010Grade Serous and Clear Cell Ovarian Carcinomas Are Worse Prognostic Factors.<\/p>\n

Iwabuchi E, Suzuki T, Ikeda K, Shibuya Y, Shigeta S, et al.
\nPathology International.<\/em> 2026; 76(2).
\ndoi:10.1111\/pin.70096<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Prognostic impact of lymphadenectomy in patients with advanced ovarian clear cell carcinoma.<\/p>\n

Fujiwara S, Shimada M, Ito Y, Takei Y, Kuroda T, et al.
\nInternational Journal of Clinical Oncology.<\/em> 2026; 31(1):184-192.
\ndoi:10.1007\/s10147-025-02926-8<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Characterization of Genetic Polymorphisms Related to 5-FU Metabolizing Enzymes in Japanese Populations.<\/p>\n

Hishinuma E.
\nYakugaku Zasshi.<\/em> 2026; 146(1).
\ndoi:10.1248\/yakushi.25-00124<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence.<\/p>\n

Shibuki T, Yamashita R, Hashimoto T, Fujisawa T, Imai M, et al.
\nInternational Journal of Clinical Oncology.<\/em> 2026.
\ndoi:10.1007\/s10147-026-03001-6<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population.<\/p>\n

Lin Y, Sasado H, Sasahira N, Ueno M, Ishii H, et al.
\nCancer Science.<\/em> 2026.
\ndoi:10.1111\/cas.70344<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

AI-based quantification of tumor-infiltrating lymphocytes with integrative transcriptomics in ovarian clear cell carcinoma.<\/p>\n

Hamada K, Hamanishi J, Ueda A, Takamatsu S, Yoshihara K, et al.
\nCancer Immunology, Immunotherapy.<\/em> 2026; 75(3):81.
\ndoi:10.1007\/s00262-026-04324-z<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome.<\/p>\n

Toyoshi E, Watanabe M, Namai F, Yamane K, Kashima T, et al.
\nJournal of Animal Science and Biotechnology.<\/em> 2026; 17(1):32.
\ndoi:10.1186\/s40104-026-01364-4<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Press release guide for genomic research and medicine: a framework co-developed with public contributors in Japan.<\/p>\n

Arakawa M, Takeuchi T, Ebana Y, Muto K, Yoshida M, et al.
\nJournal of Human Genetics.<\/em> 2026; 71(3):119-124.
\ndoi:10.1038\/s10038-026-01452-3<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Correction: Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume.<\/p>\n

Sato S, Imaeda T, Mugikura S, Mori N, Takanashi M, et al.
\nScientific Reports.<\/em> 2026; 16(1):7495.
\ndoi:10.1038\/s41598-026-40741-x<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Disparities in adverse event perception between patients and healthcare providers in gynaecologic anticancer therapy.<\/p>\n

Hashimoto H, Soejima A, Nishimura Y, Ike A, Sugawara M, et al.
\nBMJ Open.<\/em> 2026; 16(2):e107743.
\ndoi:10.1136\/bmjopen-2025-107743<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Effect of Cytochrome P450 3A4 Genetic Polymorphisms on Heme Recognition by Using Molecular Dynamics Simulations.<\/p>\n

Mizuno A, Nakayoshi T, Mizutani E, Hiratsuka M, Kato K, et al.
\nBiological and Pharmaceutical Bulletin.<\/em> 2026; 49(3).
\ndoi:10.1248\/bpb.b26-00029<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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High-density lipoprotein mediates silica nanoparticle recognition by the multiligand receptor SR-B1.<\/p>\n

Kurotobi M, Yamaguchi SI, Koyama H, Kinoshita K, Nakayama M.
\nJournal of Biological Chemistry.<\/em> 2026; 302(3):111235.
\ndoi:10.1016\/j.jbc.2026.111235<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Detection of Epigenetically Important 5-Formylcytosine Modifications Using Novel Photoreactive Oligonucleotides Containing a Trioxsalen-Conjugated Guanosine.<\/p>\n

Mikame Y, Shirahama H, Doi K, Maekawa N, Kanazawa H, et al.
\nJournal of the American Chemical Society.<\/em> 2026; 148(2):2220-2228.
\ndoi:10.1021\/jacs.5c11463<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.<\/p>\n

Li B, Kumada K, Shimada M, Shirota H, Tokunaga H, et al.
\nThe Tohoku Journal of Experimental Medicine.<\/em> 2026.
\ndoi:10.1620\/tjem.2025.J152<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria.<\/p>\n

Ishiguro K, Midorikawa K, Shigi N, Kimura S, Liiv A, et al.
\nMolecular Cell.<\/em> 2026; 86(1):78-96.e10.
\ndoi:10.1016\/j.molcel.2025.11.018<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Synthesis and structure-activity relationship of azithromycin derivatives against non-tuberculous mycobacteria.<\/p>\n

Isozaki Y, Muzahid AA, Wakata T, Fujino M, Tanaka Y, et al.
\nEuropean Journal of Medicinal Chemistry.<\/em> 2026; 304:118520.
\ndoi:10.1016\/j.ejmech.2025.118520<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Direct cryo-EM visualization of the \u03b2-sheet structure in curved amyloid protofibril.<\/p>\n

Yamamoto N, Inoue J, Saito R, Nanatani K, Takahashi A, et al.
\nBiochim Biophys Acta – Proteins Proteomics.<\/em> 2025; 1874(1):141105.
\ndoi:10.1016\/j.bbapap.2025.141105<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment.<\/p>\n

Wen H, Suzuki T, Zhang A, Sato M, Matsumoto M, et al.
\niScience.<\/em> 2025; 28(10):113519.
\ndoi:10.1016\/j.isci.2025.113519<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Symposium report\u2014ethical and social considerations regarding return of secondary findings in atomic bomb survivors.<\/p>\n

Yoshida N, Stewart DR, Uchimura A, Arita K, Bombard Y, et al.
\nCarcinogenesis.<\/em> 2025; 46(3).
\ndoi:10.1093\/carcin\/bgaf059<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Bidirectional regulation of KEAP1 BTB domain-based sensor activity.<\/p>\n

Suzuki T, Takagi K, Iso T, Wen H, Zhang A, et al.
\nRedox Biology.<\/em> 2025; 87:103885.
\ndoi:10.1016\/j.redox.2025.103885<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Advancements in Whole-Genome Sequencing Protocols: A Decade of In-House Operations and Quality Controls at the Tohoku Medical Megabank.<\/p>\n

Katsuoka F, Kawashima J, Tadaka S, Otsuki A, Okamura Y, et al.
\nJMA Journal.<\/em> 2025; 8(4).
\ndoi:10.31662\/jmaj.2025-0159<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders.<\/p>\n

Koketsu A, Fukase S, Tamahara T, Saito T, Ito A, et al.
\nOral Diseases.<\/em> 2025.
\ndoi:10.1111\/odi.70115<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7.<\/p>\n

Miyauchi Y, Koba H, Sawai M, Kansui H, Takechi S, et al.
\nJournal of Biological Chemistry.<\/em> 2025; 301(9):110502.
\ndoi:10.1016\/j.jbc.2025.110502<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Plasma Lysophosphatidylcholine Levels Correlate with Prognosis and Immunotherapy Response in Squamous Cell Carcinoma.<\/p>\n

Iwasaki T, Shirota H, Hishinuma E, Kawaoka S, Matsukawa N, et al.
\nInternational Journal of Molecular Sciences.<\/em> 2025; 26(15):7528.
\ndoi:10.3390\/ijms26157528<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

JG2: an updated version of the Japanese population-specific reference genome.<\/p>\n

Sriwichaiin S, Makino S, Funayama T, Otsuki A, Kawashima J, et al.
\nHuman Genome Variation.<\/em> 2025; 12(1):21.
\ndoi:10.1038\/s41439-025-00326-y<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Elucidation of the structure and molecular mechanisms of the aspartate antiporter.<\/p>\n

Nanatani K, Guan L, Kanno R, Watanabe S, Katsube S, et al.
\nCommunication Biology.<\/em> 2025; 8(1):1359.
\ndoi:10.1038\/s42003-025-08676-7<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population.<\/p>\n

Ohmori Y, Hishinuma E, Suzuki Y, Ueda A, Kijogi CM, et al.
\nBiochemical Pharmacology. <\/em>2025; 242:117396.
\ndoi:10.1016\/j.bcp.2025.117396<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Evaluation of the functional impact of rare CYP2C19 missense variants identified in understudied Populations: An Integrated in silico and in vitro analysis.<\/p>\n

Saleous R, Hishinuma E, Al-Mahayri ZN, Ueda A, Suzuki Y, et al.
\nBiochemical Pharmacology. <\/em>2025; 242:117350.
\ndoi:10.1016\/j.bcp.2025.117350<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Systemic activation of NRF2 contributes to the therapeutic efficacy of clinically-approved KRAS-G12C anti-cancer drugs.<\/p>\n

Baird L, Zhang L, Hidaka T, Xi L, Wang K, et al.
\nBritish Journal of Cancer. <\/em>2025; 133(9):1377-1390.
\ndoi:10.1038\/s41416-025-03162-7<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts.<\/p>\n

Lin MR, Wu IW, Chou WH, Lin YF, Hung KY, et al.
\nJournal of Biomedical Science. <\/em>2025; 32(1):72.
\ndoi:10.1186\/s12929-025-01168-0<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study.<\/p>\n

Takase M, Nakaya N, Kogure M, Hatanaka R, Nakaya K, et al.
\nCardiovascular Diabetology. <\/em>2025; 24(1):335.
\ndoi:10.1186\/s12933-025-02849-8<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Protein Data Bank Japan: Computational Resources for Analysis of Protein Structures.<\/p>\n

Bekker GJ, Nagao C, Shirota M, Nakamura T, Katayama T, et al.
\nJournal of Molecular Biology. <\/em>2025; 437(15):169013.
\ndoi:10.1016\/j.jmb.2025.169013<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Unraveling the Trajectories from Health to Disease Onset Using Health Checkup Data.<\/p>\n

Nagaie S, Mizuno S, Ogishima S.
\nStudies in Health Technology and Informatics. <\/em>2025; 7:329:1934-1935.
\ndoi:10.3233\/SHTI251286<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement.<\/p>\n

Sato K, Uehara S, Tsugita A, Ishii M, Ishiyama S, et al.
\nCell Reports. <\/em>2025; 44(7):115965.
\ndoi:10.1016\/j.celrep.2025.115965<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Development of AI Models for Early Prediction of Preterm Birth.<\/p>\n

Mizuno S, Nagaie S, Tamiya G, Kuriyama S, Obara T, et al.
\nStudies in Health Technology and Informatics. <\/em>2025; 7:329:1932-1933.
\ndoi:10.3233\/SHTI251285<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study.<\/p>\n

Sawane K, Takahashi I, Ishikuro M, Takumi H, Orui M, et al.
\nNutrition. <\/em>2025; 135:112739.
\ndoi: 10.1016\/j.nut.2025.112739<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
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Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.<\/p>\n

Fuse N, Anzawa H, Sakurai M, Motoike IN, Nagaie S, et al.
\nOphthalmology Science. <\/em>2025; 5(5):100821.
\ndoi: 10.1016\/j.xops.2025.100821<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

STAT image reporting in a large-scale cohort: types, frequency, and insights from the Tohoku Medical Megabank Brain MRI Study.<\/p>\n

Mori N, Mugikura S, Abe Y, Hozawa A, Fuse N, Yamamoto M.
\nJapanese Journal of Radiology.<\/em> 2025.
\ndoi: 10.1007\/s11604-025-01800-x<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Autoantibodies against endothelial protein C receptor and integrin \u03b1v\u03b26 predict the development of ulcerative colitis.<\/p>\n

Sawahashi M, Kakuta Y, Naito T, Okazaki S, Ohneda K, et al.
\nJournal of Gastroenterology.<\/em> 2025.
\ndoi: 10.1007\/s00535-025-02263-7<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder.<\/p>\n

Kobayashi M, Kobayashi T, Obara T, Narita A, Miyake A, et al.
\nThe Tohoku Journal of Experimental Medicine.<\/em> 2025; 2025.J074.
\ndoi: 10.1620\/tjem.2025.J074<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case\u2013Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.<\/p>\n

Sawane K, Takahashi I, Ishikuro M, Takumi H, Orui M, et al.
\nThe Journal of Nutrition.<\/em> 2025; 155(5):1498-1507.
\ndoi: 10.1016\/j.tjnut.2025.02.024<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

The clinical-grade CBP\/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs.<\/p>\n

Wang K, Baird L, Yamamoto M.
\nFree Radical Biology and Medicine.<\/em> 2025; 233:102-117.
\ndoi: 10.1016\/j.freeradbiomed.2025.03.034<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies.<\/p>\n

Kodate S, Sato M, Hishinuma E, Kojima K, Motoike IN, et al.
\nscientific reports.<\/em> 2025; 15(1):17035.
\ndoi: 10.1038\/s41598-025-01634-7<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Transforming Biobanking with AI: Perspectives from Leading Experts.<\/p>\n

Abdelhafiz AS, Henderson MK, Kozlakidis Z, Banerjee I, Mahajan G, et al.
\nBiopreserv Biobank. <\/em>2025.
\ndoi: 10.1089\/bio.2025.0101<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study.<\/p>\n

Hishinuma E, Shigeta S, Matsukawa N, Okamura Y, Motoike IN, et al.
\nInternational Journal of Molecular Sciences. <\/em>2025;26(12):5435.
\ndoi: 10.3390\/ijms26125435<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Comparison of genotypes and phenotypes for von Willebrand factor gene variants using Japanese genome database.<\/p>\n

Akimoto T, Inaba H, Ogishima S, Kumada K, Mitsuhashi A, et al.
\nBlood Vessels, Thrombosis & Hemostasis. <\/em>2025.
\ndoi: 10.1016\/j.bvth.2025.100070<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population.<\/p>\n

Ishida N, Harada S, Toki R, Hirata A, Matsumoto M, et al.
\nJournal of Diabetes Investigation. <\/em>2025.
\ndoi: 10.1111\/jdi.14377<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits.<\/p>\n

Toki R, Fushiki S, Kojima S, Sutoh Y, Otsuka-Yamasaki Y, et al.
\nScientific Reports. <\/em>2025;15(1):14569.
\ndoi: 10.1038\/s41598-025-98992-z<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study.<\/p>\n

Nagino K, Akasaki Y, Fuse N, Ogishima S, Shimizu A, et al.
\nJMIR Research Protocols. <\/em>2025;14:e67862.
\ndoi: 10.2196\/67862<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Prevalence and Associations of Epiretinal Membrane by OCT in a Japanese Population-Based Cohort: Tohoku Medical Megabank Organization Eye Study.<\/p>\n

Shiraki A, Hirayama A, Fuse N, Kawasaki R, Fujimoto S, et al.
\nOphthalmology Sciense. <\/em>2025;5(4):100752.
\ndoi: 10.1016\/j.xops.2025.100752<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Double prenylation of budding yeast Ykt6 regulates cell wall integrity and autophagy.<\/p>\n

Tateishi M, Goto K, Hishinuma E, Matsukawa N, Kishimoto T, et al.
\nJournal of Biological Chemistry. <\/em>2025;301(4):108384.
\ndoi: 10.1016\/j.jbc.2025.108384<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Regional Differences in the Frequency of BRCA1<\/em> and BRCA2<\/em> Variants in Northeastern Japan: A Cohort Study.<\/p>\n

Shirota H, Miyake A, Kawamura M, Suzuki S, Saito K, et al.
\nCancer Medicine.<\/em> 2025;14(8).
\ndoi: doi:10.1002\/cam4.70443<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile.<\/p>\n

Narita D, Hishinuma E, Ebina-Shibuya R, Miyauchi E, Matsukawa N, et al.
\nLung Cancer<\/em>. 2025;108082.
\ndoi: 10.1016\/j.lungcan.2025.108082<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.<\/p>\n

Mori N, Mugikura S, Hozawa A, Taira M, Hashizume H, et al.
\nThe Tohoku Journal of Experimental Medicine.<\/em> 2025;2025.J006.
\ndoi: 10.1620\/tjem.2025.J006<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Shared decision-making in patients with gynecological cancer and healthcare professionals: a cross-sectional observational study in Japan.<\/p>\n

Abe M, Hashimoto H, Soejima A, Nishimura Y, Ike A, et al.
\nJournal of Gynecologic Oncology.<\/em> 2025;36.
\ndoi: 10.3802\/jgo.2025.36.e47<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan.<\/p>\n

Ohneda K, Suzuki Y, Hamanaka Y, Tadaka S, Shimada M, et al.
\nJournal of Human Genetics.<\/em> 2025.
\ndoi: 10.1038\/s10038-024-01314-w<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Breast cancer surveillance for epithelial ovarian cancer patients with BRCA1<\/em> and BRCA2<\/em> pathogenic variants: a single-center retrospective study.<\/p>\n

Hasegawa-Minato J, Tochigi M, Miyahara S, Kudo K, Shibuya Y, et al.
\nJapanese Journal of Clinical Oncology.<\/em> 2025.\u00a0
\ndoi: 10.1093\/jjco\/hyaf010<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Protein Data Bank Japan: Improved tools for sequence\u2010oriented analysis of protein structures.<\/p>\n

Bekker G, Nagao C, Shirota M, Nakamura T, Katayama T, et al.
\nProtein Science.<\/em> 2025;34(3).
\ndoi: 10.1002\/pro.70052<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages.<\/p>\n

Aoyama Y, Yamazaki H, Nishimua K, Nomura M, Shigehiro T, et al.
\nBlood Journal <\/em>. 2025.
\ndoi: 10.1182\/blood.2024025402<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases<\/p>\n

Suzuki N, Kojima K, Malvica S, Yamasaki K, Chikamatsu Y, et al.
\nCommunications Medicine.<\/em> 2025;5(1):3.
\ndoi: 10.1038\/s43856-024-00708-3<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Creation of a macrolide antibiotic against non-tuberculous Mycobacterium using late-stage boron-mediated aglycon delivery.<\/p>\n

Isozaki Y, Makikawa T, Kimura K, Nishihara D, Fujino M, et al.
\nScience Advances.<\/em> 2025;11(10)
\ndoi: 10.1126\/sciadv.adt2352<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n
\n

Comprehensive Genome Profiling\u2010Initiated Tumor\u2010Informed Circulating Tumor DNA Monitoring for Patients With Advanced Cancer.<\/p>\n

Sasaki T, Hiraki H, Yashima\u2010Abo A, Nagashima H, Endo F, et al.
\nCancer Science.<\/em> 2025.
\ndoi: 10.1111\/cas.16446<\/p>\n

Original Paper<\/a><\/div>\n<\/div>\n

Past Achievements
\n2024<\/a> \/ 2023<\/a> \/ 2022<\/a> \/ 2021<\/a> \/ -2020<\/a><\/p>\n<\/div>\n<\/section>\n<\/div>\n